AIM: To prepare and submit 30ml Povidine Iodine Gargle
TYPE: Monophasic liquid for external use.
FORMULA:
Sl NO |
Ingredients | Official Formula |
Working Formula |
---|---|---|---|
1 | Povidone Iodine |
1%w/v |
0.3% w/v |
2 | Ethanol |
8.38%v/v | 2.514% v/v |
3 | Glycerine |
4% | 1.2% |
4. | Methyl Salicylate |
0.06% | 0.018% |
5 | Methanol | 0.04% | 0.012% |
6 | Saccharine sodium |
0.1% | 0.03% |
7 | Purified Water (Q.S) |
100% | 30% |
PRINCIPLE:
Povidine Iodine is iodine based product a complex of iodine and povidine which is used as an antiseptic solution. Ethanol in this preparation is used to enhance the antimicrobial action.
Glycerine is used as humectant and also increases the viscosity of the preparation which helps the preparation to remain in contact with mucous membrane for longer period. Methyl salicylate and menthol provides local analgesic effect. Menthol also gives flavourto the product and saccharine acts sweetening agent.
PROCEDURE:
- Dissolve Povidine Iodine with half quantity of purified water in one beaker. Add glycerine, menthol and saccharine sodium in it with continuous stirring.
- Dissolve methyl salicylate in ethanol in a separate beaker.
- Mix both solutions and transfer into measuring cylinder.
- Finally make up the volume with purified water.
- Transfer the preparation in narrow mouth amber colored container and close thoroughly. Lable and submit.
CATEGORY: Antiseptic in the local infections of the mouth and oropharanyx.
DIRECTION: Dilute with equal quantity of warm water before use.
Not to be swallowed in large quantity.
STORAGE: Store in a well closed container.
REPORT: 30ml Povidine Iodine Gargle was prepared and submitted.
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