Aim: To prepare and submit Phenothiazine from diphenylamine.
Apparatus:
- Beaker
- Conical flask
- Measuring Jar
- Water bath
Chemical required:
- Diphenylamine
- Sulphur
- Anhydrous calcium chloride
- Aalcohol.
Principle:
Phenothiazine is prepared by fusing diphenylamine with sulphur with rapid evolution of hydrogen sulphide.
Reaction:
Procedure:
22gm of diphenylamine, 8.2g of sulfur, and 3.2 gms. of anhydrous calcium chloride are melted together. The reaction sets 140-150°C with the rapid evolution of hydrogen sulfide; by lowering the temperature, a few degrees the reaction can be slackened. when the reaction has moderated, the temperature is raised to 160°C for a time. The melt, when cool, is ground up and extracted, first with water and then with dilute alcohol. The residue consists of almost pure phenothiazine. It can be recrystallized from alcohol. Yield 93%, yellowish leaflets; m.p. 180°C.
Category: Antipsychotic.
Calculation:
Molecular formula of Diphenylamine =C12H11N
Molecular formula of Phenothiazine = C12H9NS
Molecular Weight of Diphenylamine =169g/mol.
Molecular weight of Phenothiazine =199g/mol
169g of diphenylamine gives 199 of phenothazine
11g of diphenylamine gives =X g of phenothizine =12.95g
%yield = (practical yield/Theoritical yield)X100
Report: Phenothiazine was synthesized and the percentage yield was found nto be ____%
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