Assay Of Ibuprofen

 

Aim: To Determine percentage purity of Ibuprofen.

Apparatus: 

• Erlenmeyer flask.
• Volumetric flask.
• Pipette.
• Burette.

Chemicals Required: 

• Ibuprofen
• sodium hydroxide
• Potassium Hydrogen pthallate.
• Phenlopthalin indicator.
• Phenol red.

Procedure:

 Standardization Of 0.1M NaOH:

 Weigh about 0.5gm of KHP into 250ml Erlenmeyer flask which was previously powdered and dried at 110C. Dissolve the sample in about 30ml of distilled water before you titrate. Add five drops of phenolphthalein indicator and titrate with 0.1M NaOH by constant swirling to the first appearance of a permanent pink color.

Each ml of 0.1M NaOH is equivalent to 0.02042gm of C₈H₅KO₄

Reaction:

 

Assay: Weigh accurately about 0.5gm of drug and dissolve in 100ml of ethanol (95%) and titrate with a 0.1m NaOh using phenolphthalein as an indiactor where the end point is permanent pink color. Repeat the titration with blank.

        Each ml of 0.1M NaOH is equivalent to 0.02663gm C₁₃H₁₈O₂

Percentage purity=

Report: The percentage purity of Ibuprofen was found to be ____%