AIM: To prepare and submit 30g of Carbopal gel IP.
TYPE: Semisolids.
FORMULA:
| Sl NO |
Ingredients | Official Formula |
Working Formula |
|---|---|---|---|
| 1 | Propylene glycol | 20g | 6g |
| 2 | Carbopol 934 | 1g | 0.3g |
| 3 | Triethanolamine | q.s pH7 | q.s pH7 |
| 4. | Purified water | q.s to 100 | q.s to 30 |
PRINCIPLE: Carbopal is a synthetic polyacrylic acid with ionizable carboxyl groups. It swells when dispersed in water and hydration helps in the uncoiling of the polymeric chain. In presence of alkali, Carboxylate anions (COO− ) are generated on the backbone of the polymeric chain which repels from each other and these repulsive forces further help in the extension of polymeric chains. Thus it gives higher viscosity in presence of alkaline pH 7-8
PROCEDURE:
- Carbopal was soaked in3/4th quantity of water and kept aside for 30mins.
- Then propylene glycol was added and pH adjusted up to 7 with triethanolamine.
- The gel was filled in collapsible almunium tubes.
CATEGORY: Non medicated gel.
LABELLING DIRECTION: "FOR EXTERNAL USE ONLY"
"KEEP IN A COOL AND DRY PLACE"
DO NOT FREEZE.
STORAGE: Store in a cool dry place.
REPORT: 30g of Carbopal gel IP was prepared and submitted.
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