AIM: To prepare and submit 30g of Carbopal Gel IP.
TYPE: Semisolid.
FORMULA:
| Sl NO |
Ingredients | Official Formula |
Working Formula |
|---|---|---|---|
| 1 | Propylene glycol |
20g | 6g |
| 2 | Carbopol 934 |
1g | 0.3g |
| 3 | Triethanol amine |
Q.S pH 7 | Q.S pH 7 |
| 4. | Purified water |
Q.S to 100 | Q.S to 30 |
PRINCIPLE: Carbopol is a synthetic polyacrylic acid with ionizable carboxylic groups. It swells when dispersed in water and hydration helps in the uncoiling of the polymeric chain. In presence of alkali, Carboxylate anions(COO) are generated on the backbone of the polymeric chain which repels from each other and these repulsive forces further help in the extension of polymeric chains. thus it gives higher viscosity in presence of alkaline pH 7-8.
PROCEDURE:
- Carbopol was soaked in3/4th quantity of water and kept aside for 30 mins.
- Then propylene glycol was added and pH adjusted up to 7with triethanolamine.
- The gel was filled in collapsible aluminum tubes.
CATEGORY: Non medicated gel.
LABELING DIRECTION: For External use only.
Keep in a cool and dry place.
Do not freeze.
REPORT: 30g of Carbopal Gel IP was prepared and submitted.
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