Aim: To identify and correct therapeutic incompatibility between Aspirin and Probenecid
Rx
Aspirin 1.5g
Probenecid 1g
Principle:
Above prescription is an example for therapeutic incompatibility due to antagonistic effect of combination drugs which neutralizes the effect of each drug.
These drugs are used to treat Gout( an inflammatory condition associated with severe pain and tenderness in joints and is characterized by increased blood uric acid well). The pain and tenderness is due to accumulated uric acid in joints.
Treatment protocol includes an analgestic to relieve the pain and a drug to reduce blood uric acid level. Aspirin(analgestic) if given with Probenecid(uric acid reducer) results in therapeutic incompatibility due to their antagonistic property.
Prescribing Ibuprofen, an equally effective analgestic over Aspirin can prevent incompatibility.
Direction: Bring to the notice of the prescriber regarding incompatibility and replace Aspirin with Ibuprofen.
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