Aim: To prepare and submit 5 Chloral hydrate suppositories 

Apparatus: 

  • China dish
  • Glass rod
  • Pestle and mortar
  • Spatula
  • Suppository moulds
  • Tiles
  • Water bath
Other materials required: Liquid paraffin, Ice

Note: Use 2g mould, displacement value of chloral hydrate is 1.5

Formula:
Ingredients Official Formula Working Formula
Chloral hydrate 200mg 1.2g
Cocoa butter quantity sufficient 11.2g


Principle:
Since cocoa butter does not contract sufficiently on cooling, to facilitate easy removal of suppositories the moulds are lubricated. To preserve the stable 'β'  form of base, it is heated on water bath till 2/3 rd gets  melted. Boric acid is insoluble in cocoa butter hence it is uniformly dispersed in molten base base with stirring. Agitation and quick pouring is essential to avoid settling of insoluble solid and solidification of base in dish , respectively. To prevent formation of depression in the suppository upon cooling , overfilling is advised. Since suppositories don not fracture upon sudden cooling, congealing can be done on ice.

Procedure: 
  • Calculate the quantity of ingredients for 1 extra suppository to allow the unavoidable wastage (for 6 suppositories)
  • Heat calculated amount of cocoa butter in a dish on a water bath 
  • Take out the dish when 2/3 rd  of base is melted, add chloral hydrate and mix well(powdered drug should be missed with part of molten base on warm ointment slab by spatulation. Resulting mass should be transferred back to dish with continuous agitation and heat gently if needed)
  • Pour the molten mass into previously cleaned and lubricated mould kept on ice till overflow 
  • After complete solidification of mass, trim off the excess mass with a knife
  • Open the mould and remove the suppositories
  • Wipe the excess oil with filter paper, wrap individual suppository with butter paper
  • Pack in partitioned card board box.
Category: Hypnotic(CNS depressant , produce calming effect without inducing sleep)

Storage :  Store in cool place

Direction: For rectum, insert one at night.


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