Aim:
To prepare, label and submit 30ml of Pediatric Paracetamol Elixir B.P.C
Apparatus required:
- Beaker
- Glass rod
- Glass funnel
- Measuring cylinder
Formula:
| Ingredients |
Official Formula | Working Formula |
|---|---|---|
| Paracetamol | 02.400gm | 0.72gm |
| Raspberry Syrup | 30.000ml | 9ml |
| Alcohol(95%) | 10.000ml | 3ml |
| Propylene glycol | 10..000ml | 3ml |
| Chloroform Spirit | 02.000ml | 0.6ml |
| Amaranth Solution | 00.200ml | 0.06ml |
| Glycerine qs to |
100ml |
30ml |
Principle:
Paracetamol has low water solubility; hence it is dissolved in a mixture of alcohol, propylene glycol and chloroform spirit(co solvents). As this preparation is meant for children, amount of alcohol is limited. But at this concentration of alcohol paracetamol is not completely soluble and hence mixture of solvents is used. Chloroform spirit and alcohol together acts as preservative. Amaranth solution acts as coloring agent, concentrated raspberry syrup and invert syrup as sweetening agent. Glycerine adds on taste and acts as viscous vehicle.
Since sucrose is insoluble in alcohol, instead of simple syrup invert syrup is used to avoid precipitation of sucrose.
Procedure:
- Take 3ml of alcohol(95%) 3ml of Propylene glycol 0.06ml of chloroform spirit in a clean dry place beaker mix well.
- Weigh 0.72gm of Paracetamol dissolve in the above mixture with continuous mixing
- Add 9ml of Raspberry syrup & 0.06ml of Amaranth solution mix well
- Transfer to a measuring cylinder adds sufficient Glycerine to make upto 30ml mix well
- Transfer to clean and dry bottle, close the bottle tightly, label and submit.
Category: Analgestic(relieve pain without causing loss of consciousness ) and antipyretic(reduces elevated body temperature to normal level)
Dose: 1-5ml
Storage: Store in well closed light resistant container
Caution: Do not use for more than two days. To be given under medical supervision for infants.
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